There is an interesting experimental work related to the condensed matter simulation of physics in space-times with D=4 spatial dimensions meaning that one would have D=1+4=5-dimensional space-time (see this and this). What is simulated is 4-D quantum Hall effect (QHE). In M-theory D= 1+4-dimensional branes would have 4 spatial dimensions and also 4-D QH would be possible so that the simulation allows to study this speculative higher-D physics but of course does not prove that 4 spatial dimensions are there.
In this article I try to understand the simulation, discuss the question whether 4 spatial dimensions and even 4+1 dimensions are possible in TGD framework in some sense, and also consider the general idea of the simulation higher-D physics using 4-D physics. This possibility is suggested by the fact that it is possible to imagine higher-dimensional spaces and physics: maybe this ability requires simulation of high-D physics using 4-D physics.
See the chapter Quantum Hall effect and Hierarchy of Planck Constants or the article Condensed matter simulation of 4-D quantum Hall effect from TGD point of view.